Mac OSX Install.

Source

Use the following steps to run Tuxemon on Mac OSX Yosemite from source:

1. From a terminal, install homebrew:
ruby -e "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/master/install)"

2. Instruct homebrew that you want to use python, then update.
brew tap Homebrew/python
brew update

3. Install homebrew's version of python as it is newer/better than the default:
brew install python

4. Install the dependencies for pygame:
brew install sdl sdl_image sdl_ttf portmidi hg git
brew install sdl_mixer --with-libvorbis

5. Install all of the dependencies via pip:
pip install pytmx
pip install pillow
pip install netifaces
pip install six
pip install neteria
pip install hg+http://bitbucket.org/pygame/pygame

6. Download the latest development version of Tuxemon here and extract the archive to a folder.

7. Run the game by running ulimit -n 10000; python tuxemon.py from a terminal.